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[DOI] [PMC free article] [PubMed] [Google Scholar] [42].Mintzer MA, Simanek EE

Blockade of mTOR signaling via rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions

For elderly patients with CVDs, personalized dietary and exercise interventions significantly improve symptomsparticularly in HFwhile optimizing blood pressure, lipid profiles, and insulin sensitivity (152, 153)

They also decrease inflammatory cytokine levels in various pathologies (35, 36)

Additionally, EGCG exhibits anti-inflammatory effects by inhibiting microglial activation, reducing TNF-, IL-1, and IL-6, and attenuating the NF-B pathway in the injured rat brain (Li R

Nuclear factor kappa beta (NF-kB) is a pleiotropic transcriptional factor which is present within the cell nucleus and activates molecular mechanisms related to oxidative stress, inflammation, endothelial dysfunction, myocardial hypertrophy and fibrosis and cardiomyocyte apoptosis (97)
