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However, contradictory findings were obtained in another recent study, where genetic deletion of NOX1 or NOX2 did not improve survival in SOD1 G93A mice (Seredenina et al., 2016)

Normalization, fold changes, and p -values were calculated using criteria provided by NanoString

Histological analysis further confirmed substantial improvement in tendon healing quality after 2 weeks of treatment (Li et al., 2018)

The OZ group showed clinically significant improvement in the mean values of all the parameters

doi: 10.1002/adtp.202300024 9 FinkelsteinSKaneeLBehroozianTWolfJRvan den HurkCChowEet al

Future research must prioritize the development of cardiac-specific delivery systems for lymphangiogenic factors, the discovery of small-molecule agonists of key pathways like VEGFR-3, and a deeper understanding of how lymphatic therapy integrates with established heart failure pharmacotherapies (109, 203)