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It was found that the effective chemopreventive agents derived from plants that can inhibit the activation of PI3K/Akt/mTOR pathway provide a rationale strategy to overcome the incidence of many physiological and pathological conditions, such as cell proliferation, differentiation, metabolism, angiogenesis and survival in cancer cells

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Like other toxic heavy metals, Cd is greatly concentrated in the upper levels of food chain (Jrup and Akesson, 2009)

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