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While the metric order,

1) System X c /GSH/GPX4 pathway Reduced glutathione (GSH) is an important antioxidant and free radical scavenger synthesized from glutamate, cysteine, and glycine [18]

Defects in SDH subunits lead to succinate accumulation and oncometabolite-driven pseudohypoxia and are strongly linked to hereditary paragangliomas, pheochromocytomas and certain renal cell carcinomas, underscoring the essential role of complex II in metabolic and redox homeostasis 78,79

13 The relatively high redox potential of the Cu 2+/ Cu + system is utilized for oxidation reactions, such as the generation of superoxide by superoxide dismutase (SOD) and catechols by tyrosinase

Samples were diluted in reaction buffer to accurately detect glucose levels and frozen at 20 C until use

Traverse City, Michigan, November 2, 2001