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Patients with an isolated CNS relapse who show greater than 0.01% MRD in a morphologically normal marrow have a worse prognosis (5-year EFS rate, 30%) than do patients with either no MRD or MRD less than 0.01% (5-year EFS rate, 60%).[218] Isolated CNS relapse Standard treatment options for childhood ALL that has recurred in the CNS include the following: Systemic and intrathecal chemotherapy

[DOI] [PMC free article] [PubMed] [Google Scholar] Colanero S, Tagliani A, Perata P, Gonzali S (2020) Alternative splicing in the Anthocyanin fruit gene encoding an R2R3 MYB transcription factor affects anthocyanin biosynthesis in tomato fruits