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Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts

Uversky, 2021

A "Strong" rating indicates support from multiple well-designed trials, "Moderate" suggests promising but less consistent findings, and "Limited" or "Emerging" applies to areas with early-stage, small, or mixed research

& Liang, J

ANO1 is another calcium-activated chloride channel that plays a central role in the proliferation, invasiveness, and apoptosis of various malignant tumors (347, 348)

In a randomised, placebo-controlled study comparing the effects of erdosteine and NAC treatment for 10 days in 30 patients with mild-to-moderate COPD who were current smokers, both erdosteine and NAC caused significant reductions in ROS blood levels, but only erdosteine lowered 8-isoprostane levels and restored the short-term FEV 1 response to salbutamol [64]