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Description
When a sleep disturbance is determined to be directly and temporally linked to another mental, physical, or sleep problem, comorbid insomnia is diagnosed (Morin & Benca, 2011).The DSM-5 and ICSD-3 criteria require a subjective report of a sleep complaint (difficulty falling asleep, staying asleep, or waking up early) occurring at least three times a week for three months, along with at least one related daytime impairment (fatigue, attention impairment, mood disturbance, or impaired performance), in order to diagnose chronic insomnia (Saddichha, 2010)

doi: 10.1073/pnas.0810962106

None of these patients have the period of apparently normal development, and in fact, some continue to regress after 6 months, unrelated to the epileptic encephalopathy

Summary Choline is a vitamin-like essential nutrient and a methyl donor involved in many physiological processes, including normal metabolism and transport of lipids, methylation reactions, and neurotransmitter synthesis

Resting State Functional Connectivity Patterns Associated with Pharmacological Treatment Resistance in Temporal Lobe Epilepsy. Epilepsy Research 149 (November 17, 2018): 3743

Oolong tea extract and citrus peel polymethoxyflavones target the TMAO formation process and lower vascular inflammation [154]
