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Our data using the CO donor CORM2 indicate that CO inhibits aminoglycoside-induced hair cell death, suggesting that HSP32/HO-1-mediated CO production may have a role in celastrol's protective effect

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ROS generation was detected using a Leica fluorescence microscope (Leica DM6000B) and Leica LAS X software, and the quantitative analysis was performed with ImageJ