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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Rochette PJ, Bastien N, Lavoie J, Guerin SL, Drouin R

This substantial reserve explains why B12 deficiency takes years to develop even when dietary intake ceases

If your B12 deficiency has caused nerve damage, you may experience symptoms such as: Numbness or tingling (pins and needles) in your hands or feet Difficulty with balance, coordination, or walking Significant memory loss, confusion, or cognitive changes If you have any of these neurological manifestations, intramuscular injections remain the absolute gold standard for treatment [18] [19]

Aging , stress , poor diet , alcohol , and certain medications can deplete glutathione levels

While slowing down the drip rate can help reduce discomfort, the side effects are still common and can turn an otherwise beneficial treatment into an uncomfortable experience