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This receptor activation increases melanin synthesis, resulting in a gradual darkening of skin tone

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Footnotes 1Staiano C, Garca-Corzo L, Mantle D, Turton N, Millichap LE, Brea-Calvo G, Hargreaves I

Brembu, T., Mhlroth, A., Alipanah, L., & Bones, A

Research on CRC metastasis demonstrates significantly elevated SREBP2 expression in liver metastases compared to primary tumorsa phenomenon not observed in brain or lymph node metastasesindicating pathway-specific activation of cholesterol synthesis in hepatic metastasis

However, although NHRs are important targets for drugs that moderate these metabolic disorders, the NHR-mediated regulatory networks that govern fat usage are notably complex and poorly understood