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4.15 RT-qPCR analysis in transgenic CL4176 The collected samples were processed identically to those in the metabolomics analysis, as detailed in Sect

This, in turn, can restrict or competitively inhibit SSADH activity, indirectly influencing GABA metabolism (Kilian et al

These baseline measurements become the reference against which all changes are evaluated

This led us to hypothesize that AML cells initiate the de novo serine biosynthesis pathway in response to crisantaspase treatment and that inhibiting this pathway in combination with crisantaspase would enhance AML cell death

Introduction of a primary carboxamide in the C-terminal (cf

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