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In the development of inflammation, prostaglandins, especially prostaglandin E2 (PGE2), are major players alongside with chemo- and cytokines, like tumor-necrosis-factor alpha (TNF) and interleukin-1 beta (IL-1)

It is synthesized in the body from the amino acids lysine and methionine and is found in high concentrations in the brain, liver, and muscles

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