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1 Functional validation of shRNA screen hits including Gstt1 in metastatic cells

FOXO1 respectively inhibits and enhances eNOS and inducible-NOS (iNOS), contributing to pro-atherogenic effects, as confirmed by the reduced progression of atherosclerosis in FOXO1-deleted mouse models [71, 72]

Superoxide radical anion (O 2 ) is considered the initial ROS formed by complexes I and III of the mitochondrial respiratory chain

The addition of a figure would also be great to provide a "big picture" snapshot of where these various cooperative and competitive behavioral effects may be occurring. Response: We appreciate your compliments regarding the paper

10.1002/glia1082 93

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