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The compound has been found to operate in the postrema and nucleus of the hindbrain solitary tract in order to both induce satiety and regulate appetite by acting on receptors found in the laterodorsal tegmental nucleus, ventral tegmental area, and the hypothalamus [1]

PloS One 15(11):e0240784 Norrie J, Heitger M, Leathem J et al (2010) Mild traumatic brain injury and fatigue: a prospective longitudinal study

However, Sp-L-DOPA combination showed consistent negative geotaxis even during the wearing-off phase, representing substantial alleviation of L-DOPA toxicity and promotion of enhanced mitochondrial and cellular health in dopaminergic neurons

This demonstrates the antioxidants ability to inhibit the formation of blue formazan (Parejo et al

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

doi: 10.1002/brb3.558
