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Mechanisms of action It has become common to discover a binding of a small molecule to another molecule such as a protein, and assume that this interaction, leading to activation or inhibition of the target, constitutes the mechanism of action of the small molecule at a physiological level

Emerging evidence suggests the existence of a gut-joint axis, wherein the gut microbiome influences the pathogenesis of joint diseases via discrete mechanisms

Key epigenetic factors such as NEUROD2 and MECP2 play significant roles in epilepsy

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of these, 162 initiated insulin therapy (insulin therapy group), whereas 183 did not (non-insulin therapy group) during the follow-up period (median 3.0 years)

Le Minh, G., Esquea, E