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Therefore, nanomedicine is of great significance for the remodeling of TME [93]

6.1.1 Enhancing bile acid synthesis and excretion Penthorum chinense Pursh induces an alternative pathway of chenodeoxycholic acid (CDCA) synthesis, activates FXR, promotes BA excretion, and reduces cholesterol levels, effectively ameliorating NAFLD in mouse models (Zhang et al., 2023)

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Diabetologia 53(8):16561668 Tamaki M, Fujitani Y, Hara A, Uchida T, Tamura Y, Takeno K et al (2013) The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance