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For instance, 4-hydroxynonenal treatment reduces tight junction protein expression in the colon, boosts bacterial movement from the gut to circulation, and intensifies Toll-like receptor-4 signaling activation (37)

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Biochem Biophys Res Commun 324 : 231235 Wong A, Yang J, Cavadini P, Gellera C, Lonnerdal B, Taroni F, Cortopassi G 1999 The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis

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