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Augmented circulating levels of GDF15 may lead to weight loss and anorexia in patients with CC and are associated with reduced survival (Lerner et al., 2015

L.BagdasD.AlkhlaifY.AlsharariS
An excess of insulin promotes increased uptake of FFA in the heart due to up regulation of the cluster differentiation protein 36 (CD36) [151], which is a potent FFA transporter

[DOI] [PubMed] [Google Scholar] 60.Celestino-Soper PB, Violante S, Crawford EL, Luo R, Lionel AC, Delaby E, Cai G, Sadikovic B, Lee K, Lo C, Gao K, Person RE, Moss TJ, German JR, Huang N, Shinawi M, Treadwell-Deering D, Szatmari P, Roberts W, Fernandez B, Schroer RJ, Stevenson RE, Buxbaum JD, Betancur C, Scherer SW, Sanders SJ, Geschwind DH, Sutcliffe JS, Hurles ME, Wanders RJ, Shaw CA, Leal SM, Cook EH, Jr, Goin-Kochel RP, Vaz FM, Beaudet AL, et al

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The developed fermentation does not depend on petrochemical synthesis of achiral precursors, but instead makes use of renewable feedstocks
