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112 Chronic inflammation in the TME, which is mediated by cytokines such as IL-6, IL-8, and TNF-, can drive epigenetic and transcriptional reprogramming via the NF-B, JAK/STAT, and COX-2 pathways

Science 247 , 456459 (1990)

Relationship to vesperlysine A and the advanced Maillard reaction in aging, diabetes, and cataractogenesis

Statements Author contributions SC: Writing original draft

The primary mechanism of action involves the activation of telomerase, an enzyme responsible for maintaining and extending telomeresthe protective caps at the ends of chromosomes