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Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase

Damage to Meyer's loop, which carries visual fibers from the inferior retina through the temporal lobe, classically produces a contralateral left superior quadrantanopia

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Thus, we posit that the dose of APR-246 needed to sufficiently restore wildtype function and overcome dominant negative effects of remaining p53 mutants is the major limitation in these studies
