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Similar to cagrilintide, pramlintide is primarily eliminated via the kidneys and, in a pharmacokinetic study in participants with type 1 diabetes, no statistically significant differences were noted in total (AUC 0- ) and peak ( C max ) exposure after administration of a single pramlintide 60 g dose in participants with mild, moderate or severe renal impairment compared with those with normal renal function, although inter-patient variability was high [20]

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Nat Cell Biol 3:433438 Gktuna S, Canli O, Fingerle A, Horst D, Diamanti M, Pallangyo C, Bennecke M, Nebelsiek T, Mankan A, Lang R et al (2014) IKK promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells

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