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The interaction between eIF4a3 and the GPx-1-SECIS element limits GPx-1 expression by competing for the binding of SBP2, thereby selectively inhibiting GPx-1 translation under conditions of selenium restriction (49)

Start with 500 mg once daily at dinner or bedtime, increase to twice a day after two weeks, and can go up to a maximal dose of 2000 mg/day

They are commonly used as a maintenance treatment after injection therapy

doi: 10.3389/fphar.2021.723233
