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Lin, E.Y

While the above evidence indicates that the mitochondrial apoptotic pathway promotes cell death, recent provocative evidence has shown that the intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in Caenorhabditis elegans by triggering a unique pattern of gene expression that modulates stress sensitivity and promotes survival (Yee et al., 2014)

10.1016/j.bbagen.2013.04.015 57 FeiC.ShenggangS

Finally, adipocyte lipolysis is involved in various diseases such as cancer, type 2 diabetes and fatty liver disease, and targeting adipocyte lipolysis is of therapeutic interest

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