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The complement system is chronically activated in hyperglycemic microenvironments, where complement components 3a (C3a) and C5a anaphylatoxins enhance macrophage chemotaxis and stimulate pro-inflammatory cytokine production, amplifying glomerular endothelial damage (86, 87)

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Bioavailability was independent of water volumes up to 120 mL

[PMC free article] [PubMed] [Google Scholar] 251.Shi M

[DOI] [PubMed] [Google Scholar] 187.Valli G., Giardina E.-G.V