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Moreover, in response to different activating stimuli following disturbances of the cellular redox status, NRF2 is stabilized, and it translocates to the nucleus where it binds to antioxidant response elements in the promoter regions of genes encoding for antioxidant, cytoprotective proteins including glutathione synthesis and reduction, as well as enzymes involved in NADPH regeneration

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doi: 10.1016/j.placenta.2020.01.015, 33