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To counteract ERS, cells initiate the UPR via three major pathwaysPERK, inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6)to coordinate adaptive repair and death decisions [206]

Then the decline in NADPH level at 340 nm was determined and GR activity was reported by means of mmol kg 1 s 1 fresh weight

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