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Furthermore, tobacco smoke is one factor that significantly contributes to oxidative stress and, consequently, to changes in the epigenetic machinery involving methylation (Mecocci and Polidori, 2012)

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Recommendations were developed from a literature review, practitioner management survey, and nominal group process involving two face-to-face meetings

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For instance, drug exposure drives the phenotypic alterations of tumor cells, including dedifferentiation, EMT or trans-differentiation, marked by upregulated EMT-related transcriptional factors (TFs), including Zinc finger E-box binding homeobox 1 (ZEB1), ZEB2 and SLUG, that suppress pro-apoptotic proteins (BIM, BMF) and activate anti-apoptotic proteins (Bcl-xL, BCL- 2, MCL1) [38,39,40]

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