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doi: 10.2174/1389450053174596

A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

Tirzepatide produces 10 to 15 times more weight loss than AOD 9604 demonstrated in its best clinical trial

State Reconstituted (liquid) Storage 35.6-46.4F (2-8C) Notes Refrigerate

Claims of meaningful human fat loss should therefore be read as unproven hypotheses , not established outcomes

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