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Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

PubMed , The Journal of Biological Chemistry , vol

The safety data, while reassuring, comes primarily from shorter-duration studies

[DOI] [Google Scholar] 125.Chen Y

Although NRF2 activation is beneficial in diseases characterized by oxidative stress, including neurodegenerative, cardiovascular, and metabolic disorders [8, 9], in cancer, its persistent activation can be maladaptive

They discovered that depleting the iSPNs of TrkB signalling leads to increased striatal dopamine due to an increase in the number of dopaminergic cells in the midbrain dopaminergic areas switching from a low dopamine-producing state to a high dopamine-producing state, resulting in striatal neuron vulnerability and motor dysfunction