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[DOI] [PubMed] [Google Scholar] 53.Yip KH, Kolesnikoff N, Yu C, Hauschild N, Taing H, Biggs L, Goltzman D, Gregory PA, Anderson PH, Samuel MS, Galli SJ, Lopez AF, Grimbaldeston MA

This leads to NF-B-mediated expression of pro-inflammatory cytokines (IL-6 and TNF-), constituting a core mechanism of acute gout attacks

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Conversely, a healthy composition of the gut microbiota can contribute to the integrity of the intestinal barrier due to increased expression and induction of the assembly of TJ proteins, activation of mucus synthesis, and antioxidant action