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The expression level and activity of GOT2 and GPT2 in breast cancer cells were significantly higher than those in normal breast cells, which constituted the basis of glutamine addiction in breast cancer cells (Korangath et al., 2015)

5a,b), corresponding to the inability of KG, l-carnitine or acetylcarnitine to rescue histone acetylation following treatment with the HAT inhibitor (Extended Data Fig

Therefore, high doses of carnitine are required to increase muscle carnitine

Another study compared changes in ATP levels in axon terminals with or without mitochondria

biophysical Res

These defects typically manifest as severe metabolic disorders, such as cardiomyopathy, encephalopathy, and hypoglycemia