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Since substrate availability significantly influences respiratory quotient and fat oxidation rates, variations in macronutrient intake may have confounding effects that influence individual responses to L-carnitine supplementation

This is due to the fact that CaiT is an antiporter catalyzing exchange of intracellular and extracellular trimethylammonium compounds such as L-carnitine, crotonobetaine, and -butyrobetaine, while it does not catalyze uniport of L-carnitine out of the E

Your dog's body can obtain L-Carnitine from their diet, particularly from protein sources, or it can manufacture its own from amino acids (specifically, lysine and methionine)

S.Waliszewska-ProsM.OnanD.MarschollekK.WielsW.et al (2023)

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J Inherit Metab Dis 21(8):867868