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193 Furthermore, GATA4 downregulates essential ATGs, including Atg5, Atg7, Atg12 , and Becn1 , collectively diminishing autophagic flux

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This modulation of xCT activity by aberrantly active AKT may be specific to breast cancer cell lines and/or only present in cancer cells with oncogenic PI3KCA mutations as many cancer cells are cystine dependent