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The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin

Am J Physiol Endocrinol Metab (2020) 318:E52537

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Additional pharmacokinetic parameters (C max , T max , t 1/2 ) were calculated from plasma TMAO and L-carnitine concentrations using R package pracma (47)

Mitochondrial areas (m 2 ) were quantified in an investigator-blinded manner in 20 microscopic fields containing 2436 mitochondria (vehicle hearts) and 24 microscopic fields containing 1879 mitochondria (METH hearts) to calculate the average mitochondrial size and determine the number of mitochondria per microscopic field using NIH ImageJ (v1.6.0) software 32