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Compared to placebo, ALC produced a significant pain reduction equal to 20.2% (95% CI: 8.3%-32.1%, P 50% indicated a statistically significant among-study heterogeneity: in this case, studies were pooled using random-effects model

According to Saied and Hassan (2014), BPA (endocrine disruptor) such as TMX can disrupt dopaminergic transmission by altering various processes such as DA synthesis, release, and turnover, as well as the expression of both DA transporters and receptors

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