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While offering advantages over conventional treatments, the optimization of CDT efficacy presents challenges stemming from suboptimal catalytic efficiency and the counteractive ROS scavenging effect of intracellular glutathione (GSH)

Classification: Research chemical not intended for human consumption

By genetically deleting the disulfide reductase pathways from mouse liver, we uncovered an inducible, ubiquitous, cell-autonomous reductase-independent backup pathway for the generation of cysteine, driven by cystine CS bond cleavage.

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