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Stability and degradation issues may arise during the development of peptide-based therapies, as peptides often have poor stability and are prone to rapid degradation, limiting their therapeutic potential

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198 Quintana-CabreraR.QuirinC.GlytsouC.CorradoM.UrbaniA.PellattieroA.et al (2018)

Mechanistically, GTP hydrolysis is known to induce a conformational switch in the G2 loop and Cys -Pro- His Ni II -binding motif in UreG (Figure 38A), 822 and perhaps only as part of the activation complex, may weaken the Ni II affinity and allow for dissociation of Ni II into the vestibule (Figure 34, bottom )