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4 Discussion The serum serotonin levels were low before L-carnitine, L-carnitine supplementation was associated with a robust increase in peripheral serotonin and reduction of fatigue, and there was a statistically significant correlation between serum serotonin and fatigue levels in both patient groups

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Jones CL, Stevens BM, DAlessandro A, Culp-Hill R, Reisz JA, Pei S, et al

The effect is more pronounced in overweight or obese individuals and when the treatment is combined with a caloric deficit and physical activity

Pol Arch Med Wewn 97:534540 Kabbouche MA, Powers SW, Vockell A-LB, LeCates SL, Hershey AD (2002) Carnitine palmityltransferase II (CPT2) deficiency and migraine headache: two case reports