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KPV An anti-inflammatory peptide studied for gut barrier integrity, with potential applications in inflammatory bowel conditions

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SEL is conjugated with PEG using a reactive oxygen species (ROS)-responsive linker, forming a PEG-SEL prodrug that self-assembles into micelles as a delivery vehicle for OSI, co-delivering OSI and SEL nanoparticles effectively overcoming OSI resistance in NSCLC [111].For ALK-positive NSCLC patients, although there is a good response to ALK tyrosine kinase inhibitor (TKI) therapy, drug resistance eventually develops

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This observation is in tandem with the hypothesis of paracrine tumorigenesis where the enhanced secretion of VEGF by tumor cells lead to rapid propagation of these affected cells