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It has been demonstrated that chronic pain may lead to structural and functional alterations in the hippocampus, including neuronal atrophy in the CA1 and CA3 regions, reduced synaptic plasticity, and decreased functional connectivity [503]

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Psychiatry 69, e113e125

A critical gap is the identification of definitive molecular switches that determine whether the crosstalk promotes tumor cell survival or death in a given therapeutic setting, which severely impedes the rational design of pathway-specific modulators

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