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The mean fluorescence intensity of CellROX was significantly higher in immune cells from TLS than those from the spleen or peripheral blood (Supplemental Figure 4)

Early stages of stress exposure activated upregulation of galactose metabolism, tryptophan metabolism, arginine and proline metabolism, and carotenoid biosynthesis, while D-amino acid metabolism, aminoacyl-tRNA biosynthesis, arginine and proline biosynthesis, and ABC transporter pathways were downregulated (Fig

Population-level data reinforce these trends
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