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Decreased activity of GPX4 prevents the metabolism of lipid peroxides via GPX4-catalyzed glutathione (GSH) reduction reactions, resulting in the oxidation of divalent iron ions and the generation of reactive oxygen species (ROS) in lipids (19)

doi: 10.1016/0304-3835(92)90173-s

There is evidence that the monomeric (non-aggregated) and oligomeric (a few grouped together) but still soluble forms of huntingtin, and smaller fragments that can come from proteolytic cleavage are especially toxic to cells while larger, insoluble inclusion bodies might be more protective

10.1016/j.cej.2021.133816 56 MllerE.Von GuntenU.BouchetS.DrozB.WinkelL
10.1016/S0022-5347(06)00517-9 44 HellstromW

The role of magnetic susceptibility in magnetic resonance imaging: MRI magnetic compatibility of the first and second kinds
