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NRF2 provides a protective effect in melanocytes in response to both UV irradiation and oxidative stress 30,31 , through transcriptional upregulation of the antioxidant response element (ARE) genes including Superoxide dismutase-1 (SOD-1), Glutathione peroxidase-1 (GP-1), Glutathione reductase-1 (GR-1), Catalase and Heme oxygenase-1 (HO-1) 38,39,40

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We did not investigate other aspects of tau pathology such as aggregation, phosphorylation, or downstream signaling cascades

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doi:10.1186/s12885-024-12044-9

Multi-functional inhaled agents like ARINA-1 and Ensifentrine aim to provide symptom relief and address core pathologies