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Conflicts of Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: the figures in the review except Figure 1 and Figure 2 were drawn by Figdraw

L.ChengH.GrizzleW.et al (2002)

TNF- is a crucial cytokine implicated in bone destruction and osteoclast formation in RA, along with IL-1, IL-6, and IL-17, which are highly expressed in RA patients

Dunlevy LP, Burren KA, Chitty LS, et al