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Biochem Biophys Res Commun 312(4):13421348

This toxicity raises concerns about its safety and long-term use in clinical settings (138, 139)

Central mechanisms that are involved in these effects are nutrient-sensing pathways, including AMP-activated protein kinase, sirtuins, the target of rapamycin (TOR), and insulin signaling pathways, which collectively coordinate metabolic flexibility and stress adaptation

doi: 10.1007/s42000-018-0033-5 105 ChartoumpekisDVZirosPGHabeosIGSykiotisGP

Oncogene-induced Nrf2 Transcription Promotes ROS Detoxification and Tumorigenesis

These molecules stimulate an immune response and contribute to an increase in the number of macrophages within the left ventricle