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Although subgroup analyses found sig- nicant heterogeneity regardless of assay type, literature suggests that dierent assays have specic characteristics and potential pitfalls [82]

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Acknowledgements Work discussed in this Review was supported by a Wellcome Trust Senior Investigator Award (095531), the Knut and Alice Wallenberg Foundation, the Swedish Research Council, the Hartwell Foundation for Biomedical Research (201500731), the Juvenile Diabetes Research Foundation (CDA-2-2013-54) and the US NIH (DK110276)