glutathione nutrition DRUG FACTS
Description
12THREE
Physicochemical Properties The isoelectric point (pI) of AOD-9604 is approximately 8.0, reflecting its net positive charge at physiological pH
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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]
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