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iNOS is activated during inflammatory responses or hypoxia and produces large amounts of NO, which can lead to oxidative stress if not properly controlled ( In the bloodstream, NO is rapidly captured by hemoglobin, forming nitrosyl-hemoglobin (HbNO) ( 2.1.1 NO enhances erythrocyte deformability Erythrocyte deformability, the capacity of red blood cells to alter shape as they traverse narrow capillaries, is vital for effective oxygen delivery

Effect of reduced glutathione supplementation in semen extender on tyrosine phosphorylation and apoptosis like changes in frozen thawed Hariana bull spermatozoa

10.1002/(sici)1096-8628(19990528)84:3 3.3.co;2-y 577 Tebartz van ElstL.MaierS.FangmeierT.EndresD.MuellerG

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For instance, past works have demonstrated that PIC is able to reduce several proinflammatory mediators in activated immune cells and induce regulatory T cells in vitro while modulating adipocyte function [436]

Chew P, Yuen DYC, Stefanovic N et al (2010) Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse