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The issue: Plant-based PS appears to lack the molecular structure needed for cortisol reduction Clinical dosage: 400-800 mg daily (though effectiveness questionable with current sources) Comparison Table: Supplements to Lower Cortisol Natural Ways to Reduce Cortisol Supplements work best when combined with lifestyle changes that address the root causes of elevated cortisol

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Nat Rev Cancer 21:526536 Bernier M, Mitchell SJ, Wahl D, Diaz A, Singh A, Seo W, Wang M, Ali A, Kaiser T, Price NL, Aon MA, Kim EY, Petr MA, Cai H, Warren A, Di Germanio C, Di Francesco A, Fishbein K, Guiterrez V, Harney D, Koay YC, Mach J, Enamorado IN, Pulpitel T, Wang Y, Zhang J, Zhang L, Spencer RG, Becker KG, Egan JM, Lakatta EG, OSullivan J, Larance M, LeCouteur DG, Cogger VC, Gao B, Fernandez-Hernando C, Cuervo AM, de Cabo R (2020) Disulfiram treatment normalizes body weight in obese mice

161 A small molecule called divertin, which can bind specifically to the immunoglobulin-like occludin cell adhesion molecule (IgCAM) of epithelial long MLCK1, was shown to prevent cytokine-mediated MLCK1 recruitment to PAMR without interfering with other facilitative mechanisms (e.g., epithelial migration and wound repair)

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