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Morency, M., Nron, S., Iftimie, R

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Furthermore, repeated morphine treatment decreased its effectiveness by approximately 56% after 6 days

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This is typically a normal physiological response rather than a direct toxic effect

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1990 Jun 15;169(2):443-50

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Entry of the synthetic ACTH(4-10) analogue into the rat brain following intravenous injection

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